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GHK-Cu copper peptide in a ready-mixed 3 ml injection pen, from the REGENERATE + ANTI-AGING line with the gold logo. The same trusted format as our other pens, with a QR code on the pen for verification. WHAT'S IN THE BOX • 1x Pre-filled injection pen containing 50mg GHK-Cu • 1x Cartridge Pen • 10x Pen Needle Tips • 1x Pen Carry Case Keep refrigerated at 2 to 8°C. The characteristic blue colour of the solution comes from the copper, not from a dye. WHAT IS GHK-CU GHK-Cu is a tripeptide of glycine, histidine and lysine bound to a copper(II) ion. It occurs naturally in human plasma, saliva and urine. It was discovered in 1973 by Loren Pickart, who noticed that plasma from younger people keeps liver cells alive better than plasma from older people, and isolated the factor responsible for the difference. Plasma levels drop roughly two and a half times between the ages of 20 and 60. HOW IT WORKS • Stimulates fibroblasts to produce collagen, elastin and glycosaminoglycans, the main building blocks of the skin matrix. • Anti-inflammatory and antioxidant, partly by increasing superoxide dismutase activity. • Supports angiogenesis and cell migration to the site of an injury, which is why it is used in wound healing. • A Broad Institute study found it modulates the expression of around 4000 genes, including those linked to DNA repair and inflammation. This is the main argument behind the anti-aging claim. WHAT IT'S USED FOR Topical GHK-Cu is well documented and legal in cosmetics: creams and serums for wrinkles, firmness, photoaging, scars and hair growth. This is the only form with solid human studies behind it. The injectable form, like this pen, is a subcutaneous use promoted for overall tissue regeneration, whole-body skin quality, recovery after injury, hair growth and a systemic anti-aging effect. There are no clinical trials in humans for injection. The community typically uses 1 to 2 mg daily subcutaneously, so the dose range on this pen, up to 12 mg, is unusually wide. SUGGESTED DOSING Adjustable from 1 mg up to 12 mg per injection. At 2 mg daily, a 50 mg cartridge lasts about 25 days.